Dehydro Lovastatin - Names and Identifiers
Name | Dehydro Lovastatin
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Synonyms | Dehydro Lovastatin Dehydromonacolin K Lovastatin EP IMpurity C 2',3'-Anhydromonacolin K alpha,beta-Dehydrolovastatin (S)-(1S,3R,7S,8S,8aR)-3,7-dimethyl-8 Lovastatin EP Impurity C (Dehydro Lovastatin) [(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
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CAS | 109273-98-5
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Dehydro Lovastatin - Physico-chemical Properties
Molecular Formula | C24H34O4
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Molar Mass | 386.52 |
Density | 1.08±0.1 g/cm3(Predicted) |
Melting Point | 126-129°C |
Boling Point | 530.5±50.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Dichloromethane (Sparingly), Methanol (Slightly) |
Appearance | Solid |
Color | Off-White to Pale Beige |
Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
Stability | Light Sensitive |
Dehydro Lovastatin - Introduction
Dehydro Lovastatin(Dehydro Lovastatin) is a pharmaceutical impurity that is a structurally related compound of Lovastatin.
The chemical properties of deshydroxylovastatin include molecular formula C24H30O6, molecular weight 414.49g/mol. It is a colorless to slightly yellow crystal, soluble in organic solvents such as ethanol and methanol, and insoluble in water. Hydroxylovastatin is a strong steroid compound with cholesterol lowering activity similar to that of lovastatin.
Dehydroxylovastatin is an impurity, and its presence may affect the efficacy and safety of lovastatin. In pharmaceutical production, controlling and limiting the content of deshydroxylovastatin is essential to ensure the quality and stability of lovastatin.
Regarding the use of deshydroxylovastatin, it is mainly used for the purity analysis and detection of lovastatin drugs. By detecting and quantifying the content of dehydroxylovastatin, we can ensure that the quality of lovastatin meets the International Pharmacopoeia standards, and also help to evaluate the safety and efficacy of lovastatin.
As for the preparation method of deshydroxylovastatin, a common method is through chemical synthesis. Specific synthetic processes may involve multiple reactions and the use of specific reagents and catalysts. The preparation process needs to be carried out under appropriate conditions to ensure the purity and quality of the product.
Regarding the safety information of deshydroxylovastatin, since it is mainly present as an impurity of the lovastatin drug, the relevant safety information is mainly about lovastatin itself. Patients who use lovastatin should follow the doctor's recommendations and pay attention to compliance with the instructions for use and dosage of the drug. Lovastatin may cause some side effects such as headache, muscle pain, abnormal liver function, etc. Before using lovastatin, factors such as the individual's health status and drug interactions should be considered and follow the guidance of a medical professional.
Last Update:2024-04-09 22:09:11